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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providereview focuses on the recent research and development of agents against ZIKV infection by repurposing clinicaldrugs.

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1,   Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: practice of drugs, construction of the pharmacy discipline, cultivation of pharmaceutical professionalsthe new drug research and development based on integrative pharmacy, the design idea of integrative drugspharmacy should be developed,and a new drug development system should be established for integrative drugsTo promote the clinical application of integrative pharmacy, patient-centered clinical medication guidanceTimesNewRomanPSMT">be enriched, and the rational application of integrative drugs

Keywords： integrative pharmacy     integrative drugs     new drug development     drug evaluation     clinical medication guidance    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supportedunderstanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)for Chinese BCL patients on the basis of the current application status of oral drugs in China, combinedThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patientsWith the deepening of research and the development of standardized clinical applications, oral medications

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 411-417 doi: 10.1007/s11684-013-0293-z

Abstract: telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugsThese results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres

Keywords： telomere     antineoplasic drugs     conventional chemotherapies    

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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1501-8

Abstract:

• Oxidation of methotrexate by high-valent metal-oxo species was first explored.

Keywords： Anticancer drugs     High-valent metal-oxo species     Oxidation kinetics     Reaction mechanisms     Multi-endpoint    

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Stroke prevention: an update

Marie-Germaine Bousser

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 22-34 doi: 10.1007/s11684-012-0178-6

Abstract: modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugsreduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs

Keywords： stroke     prevention     vascular risk factors     cerebral infarction     cerebral hemorrhage     anti-thrombotic drugs    

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 374-379 doi: 10.1007/s11684-015-0411-1

Abstract:

This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of<3000 CNY, and with severe or moderate pain than those employed and unemployed (P=0.02), patients educated below college (P=0.013), with family income of≥3000 CNY (P=0.025), and with mild pain (P<0.001), respectively. Logistic regression analysis showed that the family income of≥3000 CNY (OR: 2.50, 95%CI: 1.65–4.51, P=0.021) and mild pain (OR: 1.27, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients.

Keywords： chronic pain     inpatient     oral paregoric drugs     compliance    

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Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1503-1515 doi: 10.1007/s11705-022-2294-4

Abstract: In this work, the influence of the initial chemical potential gradient, stirring speed, and polymer type on sulfamethoxazole (SMX) crystal growth kinetics was systematically investigated through density functional theory (DFT) calculations, experimental measurements and the two-step chemical potential gradient model. To investigate the influence of different conditions on the thermodynamic driving force of SMX crystal growth, SMX solubilities in different polymer solutions were studied. Four model polymers effectively improved SMX solubility. It was further found that polyvinylpyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC) played a crucial role in inhibiting SMX crystal growth. However, polyethylene glycol (PEG) promoted SMX crystal growth. The effect of the polymer on the crystal growth mechanisms of SMX was further analyzed by the two-step chemical potential gradient model. In the system containing PEG 6000, crystal growth is dominated by the surface reaction. However, in the system containing PEG 20000, crystal growth is dominated by both the surface reaction and diffusion. In addition, DFT calculations results showed that HPMC and PVP could form strong and stable binding energies with SMX, indicating that PVP and HPMC had the potential ability to inhibit SMX crystal growth.

Keywords： insoluble drugs     polymer     inhibition crystallization     crystal growth kinetics     DFT calculations    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Title Author Date Type Operation

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Journal Article

A Review of the International Workshop on “Technological Upgradation of Drugs/Pharmaceutical & Agrochemical

LI Zhengming

Journal Article

Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Journal Article

Stroke prevention: an update

Marie-Germaine Bousser

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Journal Article

Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article